Mutations in the NRAS oncogene are present in up to 20% of melanoma.Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth.IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replication stress due to dysregulated DNA replication via E
Advanced ballistic and cruise missiles Youth Clothing have become a salient feature of the Middle Eastern security landscape.More states are either developing indigenous production capabilities or importing these missiles than ever before and their use has also become a frequent occurrence in regional conflicts.Despite that the issue remains one of
The effects of climate change and variability cause a shift in climatic patterns and increasing shocks.These changes and shocks are affecting soil that is the backbone of many, particularly the farming communities.Climate-Smart soil (CSS) practices among farmers are known to rehabilitate and protect it.These practices will improve soil fertility, i
Accurate estimation of spare part demand is challenging in the case of intermittent or lumpy demand, characterised by infrequent demand occurrence and variability in demand size.While prior research has considered the effect of exogenous variables on spare part demand, there is a lack of research considering the effects of repair quality and aggreg